תזונה ותוספים The Emerging Biomolecular Role of Vitamin D in Skeletal Muscle

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    Exercise & Sport Sciences Reviews:
    April 2014 - Volume 42 - Issue 2 - p 76–81
    doi: 10.1249/JES.0000000000000013
    Articles

    The Emerging Biomolecular Role of Vitamin D in Skeletal Muscle
    Pojednic, Rachele M.1; Ceglia, Lisa2,3

    Author Information
    1Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University; 2Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center; and 3Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.

    Address for correspondence: Rachele M. Pojednic, M.S., Ed.M., Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA HNRCA at Tufts University, 711 Washington St., Boston, MA 02111 (E-mail: [email protected]).

    Accepted for publication: January 4, 2014

    Associate Editor: Roger A. Fielding, Ph.D.

    Abstract
    In this review, we summarize current evidence for a direct effect of vitamin D on skeletal muscle. A number of studies identify the receptor for 1,25-dihydroxyvitamin-D3 (vitamin D receptor (VDR)) and the enzyme CYP27B1 (1-α-hydroxylase) in muscle. We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.​

    http://journals.lww.com/acsm-essr/F...ine&et_cid=561862&[email protected]
     

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