Acta Physiol (Oxf). 2014 Jun 14. doi: 10.1111/apha.12326. [Epub ahead of print] Is blood-flow-restricted low-load resistance exercise really stress free? Noble EG. Author information Abstract Recently, there has been considerable interest in the use of blood-flow-restricted (BFR) low-load resistance exercise to induce muscle hypertrophy. This training method is purported to initiate muscle growth in the absence of the muscle damage and stress which normally accompanies traditional high-load, high intensity resistance exercise (Takarada et al. 2000) As such, it could be a valuable method to maintain or enhance muscle strength for certain clinical or aging populations and in some rehabilitation situations. This article is protected by copyright. All rights reserved.